Berberine is renowned for its ability to regulate blood sugar levels. Studies show it improves insulin sensitivity and reduces glucose production in the liver. A randomised trial found berberine as effective as metformin in lowering fasting blood sugar (5).

A study of people with diabetes, taking berberine daily showed lowered fasting blood sugar by 20% (5).

A review of 14 studies concluded that berberine exhibited significant antidiabetic effects and could be a promising therapeutic option for managing type 2 diabetes (6).

These findings highlight berberine as a natural ally for those managing diabetes or prediabetes.

Berberine has demonstrated hepatoprotective effects, supporting liver health and function. A clinical study reported that berberine could alleviate liver injury by reducing inflammation and oxidative stress (7).

Berberine plays a role in the regulation of liver enzymes involved in detoxification processes. Research suggests that it can enhance the activity of phase II detoxification enzymes, promoting the elimination of toxins from
the body (8).

It may reduce fat buildup in the liver, which could potentially protect against Non-Alcoholic Fatty Liver Disease (9).

Berberine has been shown to positively affect lipid metabolism. A study reported significant reductions in total cholesterol, triglycerides, and LDL cholesterol levels in patients with metabolic syndrome (10).

Berberine may improve cardiovascular health by addressing multiple risk factors, partly by inhibiting the enzyme PCSK9, which enhances the removal of LDL cholesterol from the bloodstream (11).

Berberine has demonstrated significant anti-inflammatory properties, which help alleviate inflammation related conditions. Studies highlight its ability to reduce inflammation by suppressing the production of inflammatory markers such as C-reactive protein and interleukin-6 (11).

Additionally, berberine modulates the NF-κB signaling pathway to exert its anti-inflammatory effects (12).

For enhanced inflammation reduction, HLTH Code's berberine also includes turmeric, a powerful anti-inflammatory agent.

Berberine is a powerful compound that supports gut health by balancing the gut microbiota and exhibiting antimicrobial properties.

It promotes the growth of beneficial bacteria while inhibiting harmful microbes, ensuring optimal gut health and improved metabolic function (13).

Moreover, berberine’s antimicrobial properties extend to its potential antibacterial, antifungal, and antiparasitic effects, making it a promising candidate for addressing various gastrointestinal infections (14).

This dual action on both gut microbiota modulation and pathogen inhibition highlights berberine’s potential in promoting a healthy digestive system.

Studies suggest berberine can help improve major risk factors for heart disease such as diabetes, high blood sugar levels, and obesity (15).

One study demonstrated that it improved symptoms and reduced the risk of death in people with heart conditions (16).

Studies have also shown that berberine can lower apolipoprotein B by 13–15% which is an important risk factor for heart disease (17)(18).

Studies suggest that it may help reduce symptoms of depression (19) (20).

Models have also shown that berberine exhibits anti-inflammatory and antioxidant properties in the brain, protecting against neurodegenerative conditions such as Alzheimer’s disease (21).

Berberine may impact neurotransmitter levels and signal transduction pathways in the brain, influencing positive mood and improved cognitive function.